In the Star Trek: The Original Series episode The City on the Edge of Forever (original broadcast date 1967 April 6), Dr. McCoy gets accidentally injected with one hundred times the standard dose (two drops) of cordrazine required to “save a man’s life.” This massive injection of that “tricky stuff” puts McCoy into a “strange, wild frenzy.”
In the television segment Spock goes to examine the contents of the hypo and he simply states, “Empty.” (See below for video.)
A decade later Bantam Books would publish Fotonovel™ No.1, the first of 12 Star Trek: TOS photonovels (a craze of the late ’70s and early ’80s) – basically photographic frames from television and film scenes with speech bubble overlays. From what I can tell the fotonovel for The City on the Edge of Forever episode was the first fotonovel of its era. It began the craze!
And the fotonovel-retelling of the segment where Spock simply speaks the word “empty” gets word-bubbled as:
And the segment from which the fotonovel takes its frames from can be watched next – which also contains a brilliant no-speech all-smiles moment from Lieutenant Sulu:
Watch the full episode over on Hulu.